Hospitals and Affordable Care Organizations
Inappropriate Antibiotic Prescriptions
• Over 130 million in outpatient setting
• 12 million in hospital setting
• 2.1 million in nursing homes
Patient mortality increases by 300% when antibiotics inappropriately prescribed
Hospital acquired infections play a large role in CMS quality programs: hospital readmission reduction, value-based purchasing and hospital acquired conditions programs.
For example, a 250-bed hospital may experience $4-5 million in penalties due to CMS quality initiatives and non-reimbursement.
• 25% to 200% of the hospital operating margin depending on hospital creditworthiness.
Average increase in medical costs per patient with antibiotic-resistant (ABR) infections: $18,588 – $29,069
Duration of hospital stays for patients with ABR infections extended 6.4 – 12.7 days
Hospital-Associated ABR Infections
• 1 in 6 central-line associated bloodstream infections
• 1 in 7 surgical site infections
• 1 in 10 catheter-associated urinary tract infections
Our facility, models and software tools can speed up drug discovery
• Preclinical infection models for assessing new chemical entities
• Tools integrating preclinical efficacy, bacterial responses and safety markers to guide drug discovery efforts
Drug Development and Clinical Trials
Integrated service enabling antibiotic drug development and translation into clinical setting
• Tools to predict treatment duration in development
• Software tools to select patients with desired antibiotic resistance profiles within hours for patient recruitment and enabling adaptive trials